In 1692, Fr Andrea, a Maltese Jesuit from Valletta, Malta, opened the building as a conservatory for girls. These were orphans, rejected by their families or had no possibility of "living honestly in poverty and misery". Fr Andrea received charitable collections from the Knights of Malta as well as from wealthy Maltese. This went in aid of the girls and to cover cost and upkeep of the conservatory. The conservatory is a corner house number 146 on St Christopher Street, Valletta, Malta. Fr Andrea also opened a second home for battered women.
The little church of Christ the Redeemer (in Maltese: Kristu Redentur), commonly known as Sagaramentini Church for the perpetual adoration, is part of the same building. It belonged to the Adoration Sisters of Mary. When the sisters left Malta in 1923, Archbishop Don Mauro Caruana called on Reverend Mother Margherita of the Franciscan Sisters of the Heart of Jesus to take over the house and church.
Without any financial assistance, the Franciscan nuns accepted the invitation and contributed by promoting a daily adoration to our Lord in Sacrament. They continued the daily exposition and adoration of the Blessed Sacrament, often hosting girls in their house of retreat.